US 11,655,241 B2
Heterocyclic compound and use thereof
Tsuneo Oda, Kanagawa (JP); Yoshiteru Ito, Kanagawa (JP); Tohru Miyazaki, Kanagawa (JP); Kohei Takeuchi, Kanagawa (JP); Norihito Tokunaga, Kanagawa (JP); Yasutaka Hoashi, Kanagawa (JP); Yasushi Hattori, Kanagawa (JP); Keisuke Imamura, Kanagawa (JP); Yuichi Kajita, Kanagawa (JP); Yuhei Miyanohana, Kanagawa (JP); Takahiro Sugimoto, Kanagawa (JP); Tatsuki Koike, Kanagawa (JP); and Dilhumar Uyghur, Kanagawa (JP)
Assigned to Takeda Pharmaceutical Company Limited, Osaka (JP)
Appl. No. 16/973,320
Filed by Takeda Pharmaceutical Company Limited, Osaka (JP)
PCT Filed Jun. 27, 2019, PCT No. PCT/JP2019/025555
§ 371(c)(1), (2) Date Dec. 8, 2020,
PCT Pub. No. WO2020/004537, PCT Pub. Date Jan. 2, 2020.
Claims priority of application No. JP2018-125334 (JP), filed on Jun. 29, 2018.
Prior Publication US 2021/0198240 A1, Jul. 1, 2021
Int. Cl. C07D 405/12 (2006.01); C07D 207/14 (2006.01); C07D 211/56 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 405/06 (2006.01); C07D 405/14 (2006.01); C07D 417/06 (2006.01); C07D 417/14 (2006.01)
CPC C07D 405/12 (2013.01) [C07D 207/14 (2013.01); C07D 211/56 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 405/06 (2013.01); C07D 405/14 (2013.01); C07D 417/06 (2013.01); C07D 417/14 (2013.01)] 15 Claims
 
1. A compound represented by the formula (I)

OG Complex Work Unit Chemistry
wherein
R1 is an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group, an optionally substituted mono- or di-C1-6 alkylamino group, an acyl group, or an optionally substituted 3- to 6-membered cyclic group;
R2 is a hydrogen atom, an acyl group, or an optionally substituted 3- to 6-membered cyclic group;
R3 and R4 are each independently a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group, or a hydroxy group;
Ring A is an optionally further substituted pyrrolidine ring;
Ring B is an optionally further substituted 4- to 7-membered ring; and
Ring C is a benzene ring optionally further substituted by 1 to 3 halogen atoms;
or a salt thereof.