US 11,654,667 B2
Flexible substrates with chemical and moisture resistance
Gary M. Skwarek, Kenilworth, NJ (US); Carl Altman, Pitman, PA (US); Jong Lee, Cressona, PA (US); Eric Rainal, Morristown, NJ (US); Awdhoot Vasant Kerkar, Rockaway, NJ (US); and Alagappan Thenappan, Hackettstown, NJ (US)
Assigned to HONEYWELL INTERNATIONAL INC., Charlotte, NC (US)
Filed by HONEYWELL INTERNATIONAL INC., Morris Plains, NJ (US)
Filed on May 1, 2020, as Appl. No. 16/864,927.
Claims priority of provisional application 62/843,947, filed on May 6, 2019.
Prior Publication US 2020/0353732 A1, Nov. 12, 2020
Int. Cl. C08J 5/18 (2006.01); B32B 27/32 (2006.01); B32B 27/36 (2006.01); B32B 27/34 (2006.01); B65D 75/30 (2006.01); B32B 37/15 (2006.01); B29C 48/00 (2019.01); B29C 48/18 (2019.01); A61M 35/00 (2006.01); B32B 27/08 (2006.01); A61K 9/70 (2006.01); B29L 31/00 (2006.01); B29K 27/00 (2006.01)
CPC B32B 27/322 (2013.01) [A61K 9/703 (2013.01); A61M 35/00 (2013.01); B29C 48/0019 (2019.02); B29C 48/0021 (2019.02); B29C 48/022 (2019.02); B29C 48/18 (2019.02); B32B 27/08 (2013.01); B32B 27/325 (2013.01); B32B 27/34 (2013.01); B32B 27/36 (2013.01); B32B 37/153 (2013.01); B65D 75/30 (2013.01); A61K 9/7038 (2013.01); A61K 9/7084 (2013.01); B29K 2027/16 (2013.01); B29L 2031/712 (2013.01); B32B 2307/518 (2013.01); B32B 2307/714 (2013.01); B32B 2307/7265 (2013.01); B32B 2439/40 (2013.01); B32B 2439/80 (2013.01); B32B 2535/00 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A transdermal drug delivery device comprising:
a chemical and moisture resistant layer comprising poly(chlorotrifluoroethylene-co-vinylidene fluoride) (“P(CTFE-co-VDF)”) copolymer, wherein the P(CTFE-co-VDF) copolymer comprises no more than about 5 wt. % vinylidene fluoride (“VDF”), based on the total weight of the copolymer, wherein the chemical and moisture resistant layer has a first side and a second side;
a second layer releasably connected to the second side of the chemical and moisture resistant layer; and
a drug located between the second side of the chemical and moisture resistant layer and the second layer,
wherein the first side of the chemical and moisture resistant layer forms an outermost surface of the transdermal drug delivery device.