US 11,654,437 B2
Assay cartridg for molecular diagnosis
Xiaojun Lei, San Jose, CA (US); and Qian Xu, San Jose, CA (US)
Assigned to QUANDX INC., San Jose, CA (US)
Filed by QuanDx Inc., San Jose, CA (US)
Filed on Oct. 23, 2019, as Appl. No. 16/660,819.
Prior Publication US 2021/0121889 A1, Apr. 29, 2021
Int. Cl. C12Q 1/6806 (2018.01); C12Q 1/686 (2018.01); B01L 7/00 (2006.01); B01L 3/00 (2006.01)
CPC B01L 7/525 (2013.01) [B01L 3/5027 (2013.01); C12Q 1/686 (2013.01); C12Q 1/6806 (2013.01); B01L 2200/027 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0867 (2013.01)] 13 Claims
OG exemplary drawing
1. An assay cartridge used in a PCR-based molecular diagnostic device, comprising
(1) an elongated body having a proximal end, a distal end and a plurality of compartments arranged between the proximal end and the distal end, said plurality of compartments includes at least
a first pipette tip holder near the proximal end, and
a second pipette tip holder near the distal end; and
(2) a seal assembly covering the elongated body comprising
a rigid frame which matches the top periphery of the elongated body, and
an elastic top mounted on the rigid frame, the elastic top comprising
a first sub-portion near the proximal end comprising a first ring structure that matches the first pipette holder, and
a second sub-portion near the distal end comprising a second ring structure that matches the second pipette holder,
wherein the compartments near the proximal end and the first pipette tip holder are arranged as a radiation pattern;
wherein the first sub-portion and/or the second sub-portion of the elastic top has a circular ripple structure; and
wherein the plurality of compartments further includes at least a PCR reaction well near the distal end, and the assay cartridge further comprises a slidable lid removably covering the PCR reaction well.