US 11,654,203 B2
Dual-targeted carbonic anhydrase ix complex and contrast agent thereof
Siao-Syun Guan, Taoyuan (TW); Tsai-Yueh Luo, Taoyuan (TW); Tse-Zung Liao, Taoyuan (TW); Cheng-Liang Peng, Taoyuan (TW); and Kun-Liang Lin, Taoyuan (TW)
Assigned to INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C, Taoyuan (TW)
Filed by Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C, Taoyuan (TW)
Filed on Oct. 26, 2020, as Appl. No. 17/79,691.
Claims priority of application No. 108142431 (TW), filed on Nov. 22, 2019.
Prior Publication US 2021/0154334 A1, May 27, 2021
Int. Cl. A61K 49/14 (2006.01); A61K 49/10 (2006.01); A61K 47/54 (2017.01); C12N 9/88 (2006.01)
CPC A61K 49/14 (2013.01) [A61K 47/54 (2017.08); A61K 49/106 (2013.01); C12N 9/88 (2013.01); C12Y 402/01001 (2013.01)] 7 Claims
 
1. A dual-targeted carbonic anhydrase IX complex, comprising:
a binding peptide with an amino acid sequence of SEQ ID NO: 1 (NHVPLSP);
a sulfonamide derivative coupled with the binding peptide; and
a metal chelating agent coupled with the binding peptide and the sulfonamide derivative;
wherein the sulfonamide derivative is acetazolamide.