US 11,654,202 B2
Nanoemulsion of iodinated fatty acids for CT imaging
Laurent Vinet, Contamine sur Arve (FR); Andrej Babic, Veigy-Foncenex (FR); and Eric Allemann, Troinex (CH)
Assigned to UNIVERSITY OF GENEVA, Geneva (CH)
Appl. No. 16/637,366
Filed by UNIVERSITY OF GENEVE, Geneva (CH)
PCT Filed Jul. 27, 2018, PCT No. PCT/EP2018/070501
§ 371(c)(1), (2) Date Feb. 7, 2020,
PCT Pub. No. WO2019/030024, PCT Pub. Date Feb. 14, 2019.
Claims priority of application No. 17185185 (EP), filed on Aug. 7, 2017.
Prior Publication US 2021/0330820 A1, Oct. 28, 2021
Int. Cl. A61K 49/04 (2006.01); A61K 9/00 (2006.01); A61K 49/00 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 49/0438 (2013.01) [A61K 9/0053 (2013.01); A61K 49/0004 (2013.01); A61K 49/0461 (2013.01); B82Y 5/00 (2013.01)] 15 Claims
 
1. A method of in vivo imaging with Computed Tomography brown and/or beige adipose tissue (BAT) in a subject, comprising a step of administering orally a contrast agent comprising iodinated fatty acids having 4 to 24 carbon atoms and/or esters and/or salts and/or mixtures thereof according to general formula I, and a step of performing a computed tomography imaging:

OG Complex Work Unit Chemistry
wherein n=2-22;
R1 is H or I, with the provisions that the number of iodine atoms is 1 to 6, and that the iodine atoms are neither geminal nor vicinal;
and where R2 is H, unsaturated or saturated, linear or branched alkyls, alkyls, alkoxyalkyl, hydroxyalkoxyalkyl, polyhydroxyalkyl, hydroxy poly alkyleneoxyalkyl.