US 11,654,186 B2
Compositions comprising sulforaphane or a sulforaphane precursor and a mushroom extract or powder
Brian Cornblatt, Westminster, MD (US); Grace Cornblatt, Westminster, MD (US); Anton Bzhelyansky, Baltimore, MD (US); and Robert Henderson, Street, MD (US)
Assigned to Nutramax Laboratories, Inc., Edgewood, MD (US)
Filed by NUTRAMAX LABORATORIES, INC., Lancaster, SC (US)
Filed on Dec. 3, 2019, as Appl. No. 16/701,644.
Application 16/701,644 is a continuation of application No. 15/244,374, filed on Aug. 23, 2016, granted, now 10,583,178.
Application 15/244,374 is a continuation of application No. 14/586,765, filed on Dec. 30, 2014, granted, now 9,421,183.
Application 14/586,765 is a continuation of application No. PCT/US2013/049248, filed on Jul. 3, 2013.
Prior Publication US 2020/0101143 A1, Apr. 2, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/716 (2006.01); A61K 31/095 (2006.01); A61K 36/064 (2006.01); A61K 36/31 (2006.01); A61K 36/07 (2006.01); A61K 38/47 (2006.01); A23L 33/105 (2016.01); A61K 31/375 (2006.01); A61K 31/7028 (2006.01); A61K 33/06 (2006.01); A61K 9/14 (2006.01); A61P 3/06 (2006.01); A61K 31/26 (2006.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01); A61K 9/28 (2006.01); A61K 31/194 (2006.01); A61K 47/42 (2017.01); A61K 31/19 (2006.01); A61K 36/28 (2006.01); A61K 36/06 (2006.01); A61K 31/357 (2006.01)
CPC A61K 38/47 (2013.01) [A23L 33/105 (2016.08); A61K 9/0053 (2013.01); A61K 9/14 (2013.01); A61K 9/28 (2013.01); A61K 31/19 (2013.01); A61K 31/194 (2013.01); A61K 31/26 (2013.01); A61K 31/357 (2013.01); A61K 31/375 (2013.01); A61K 31/7028 (2013.01); A61K 31/716 (2013.01); A61K 33/06 (2013.01); A61K 36/06 (2013.01); A61K 36/07 (2013.01); A61K 36/28 (2013.01); A61K 36/31 (2013.01); A61K 45/06 (2013.01); A61K 47/42 (2013.01); A61P 3/06 (2018.01); C12Y 302/01147 (2013.01); A23V 2002/00 (2013.01)] 29 Claims
 
1. An orally administrable composition comprising a synergistic combination of:
a sulforaphane precursor;
a glucosidase enzyme capable of converting the sulforaphane precursor to sulforaphane;
a glucosidase enzyme cofactor; and
a glucan;
the combination having a ratio of sulforaphane precursor:glucan of from about 50:1 to about 1:50.