US 11,654,156 B2
Nutritional formulations including human milk oligosaccharides and antioxidants and uses thereof
Rachael Buck, Gahanna, OH (US); Geralyn O. Duska-McEwen, Columbus, OH (US); and Joseph P. Schaller, Reynoldsburg, OH (US)
Assigned to ABBOTT LABORATORIES, Abbott Park, IL (US)
Filed by ABBOTT LABORATORIES, Abbott Park, IL (US)
Filed on Dec. 15, 2017, as Appl. No. 15/844,294.
Application 15/844,294 is a continuation of application No. 15/804,751, filed on Nov. 6, 2017, abandoned.
Application 15/804,751 is a continuation of application No. 14/195,938, filed on Mar. 4, 2014, granted, now 9,808,474, issued on Nov. 7, 2017.
Application 14/195,938 is a continuation of application No. 13/334,995, filed on Dec. 22, 2011, granted, now 8,703,737, issued on Apr. 22, 2014.
Claims priority of provisional application 61/428,861, filed on Dec. 31, 2010.
Prior Publication US 2018/0104267 A1, Apr. 19, 2018
Int. Cl. A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61K 31/702 (2006.01); A23L 33/00 (2016.01); A23L 33/12 (2016.01); A61K 31/202 (2006.01); A61K 31/7016 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/702 (2013.01) [A23L 33/12 (2016.08); A23L 33/40 (2016.08); A61K 31/202 (2013.01); A61K 31/7016 (2013.01); A61K 45/06 (2013.01); A23V 2002/00 (2013.01); A23V 2200/3202 (2013.01); A23V 2200/324 (2013.01); A23V 2250/1882 (2013.01); A23V 2250/28 (2013.01); A61K 2300/00 (2013.01)] 18 Claims
 
1. A nutritional composition comprising a human milk oligosaccharide selected from the group consisting of 6′-sialyllactose, 3′-sialyllactose, 2′-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, lacto-N-neotetraose, lacto-N-fucopentaose, and combinations thereof, wherein, when the composition is in the form of a liquid, the composition comprises:
a polyunsaturated fatty acid, wherein the polyunsaturated fatty acid comprises 0.105 mg/mL to 0.38 mg/mL of a combination of docosahexaenoic acid and arachidonic acid, wherein a ratio of docosahexaenoic acid to arachidonic acid is from 1:4 to 1:2, from about 0.5 μg/mL to about 5 μg/mL of a carotenoid, wherein the carotenoid consists of at most two of lutein, lycopene, and beta-carotene, from about 72 mg/L to about 200 mg/L of a nucleotide component, wherein the nucleotide comprises at least one salt, and wherein the nutritional composition is shelf stable from about 3 months to about 24 months.