US 11,654,138 B2
Therapeutic agents for treating and preventing autoimmune diseases and cancer and a screening method
Hamza Naim Ahmad Hanieh, Aqaba (JO)
Assigned to KING FAISAL UNIVERSITY, Hofouf (SA)
Filed by KING FAISAL UNIVERSITY, Hofouf (SA)
Filed on Mar. 3, 2021, as Appl. No. 17/191,562.
Application 17/191,562 is a division of application No. 16/920,584, filed on Jul. 3, 2020, abandoned.
Application 16/920,584 is a continuation in part of application No. 16/717,727, filed on Dec. 17, 2019, granted, now 10,709,696, issued on Jul. 14, 2020.
Application 16/717,727 is a continuation of application No. 16/396,719, filed on Apr. 28, 2019, granted, now 10,512,639, issued on Dec. 24, 2019.
Prior Publication US 2021/0186944 A1, Jun. 24, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4439 (2006.01); G01N 33/50 (2006.01)
CPC A61K 31/4439 (2013.01) [G01N 33/502 (2013.01)] 4 Claims
 
1. A method of treating an autoimmune disease, comprising administering to a subject in need thereof an effective amount of one or more Arid5a inhibitors comprising a compound having a chemical structure according to the general formula:

OG Complex Work Unit Chemistry
wherein each of R1 and R2 is independently selected from the group consisting of H, alkyl, phenyl, substituted phenyl, a 5-membered heteroaryl, and a 6-membered heteroaryl; X is selected from the group consisting of S and O; Y is selected from the group consisting of S and NH; and n is an integer selected from 0, 1, and 2; and
wherein the autoimmune disease is selected from the group consisting of multiple sclerosis, rheumatoid arthritis, and psoriasis.