US 11,654,112 B2
Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof
Chase Coffman, Boston, MA (US); Lyndon Charles, Medford, MA (US); Paul Brown, Boston, MA (US); Daniel Benjamin Dadon, Cambridge, MA (US); Lisa Liu, Somerville, MA (US); and Cory Robinson, Cambridge, MA (US)
Assigned to Elektrofi, Inc., Boston, MA (US)
Appl. No. 16/463,238
Filed by Elektrofi, Inc., Boston, MA (US)
PCT Filed Nov. 22, 2017, PCT No. PCT/US2017/063150
§ 371(c)(1), (2) Date May 22, 2019,
PCT Pub. No. WO2018/098376, PCT Pub. Date May 31, 2018.
Claims priority of provisional application 62/476,190, filed on Mar. 24, 2017.
Claims priority of provisional application 62/476,173, filed on Mar. 24, 2017.
Claims priority of provisional application 62/468,735, filed on Mar. 8, 2017.
Claims priority of provisional application 62/468,727, filed on Mar. 8, 2017.
Claims priority of provisional application 62/425,399, filed on Nov. 22, 2016.
Prior Publication US 2019/0374470 A1, Dec. 12, 2019
Int. Cl. A61K 9/16 (2006.01); A61K 39/395 (2006.01); A61K 9/50 (2006.01); B05B 5/025 (2006.01)
CPC A61K 9/1682 (2013.01) [A61K 9/5089 (2013.01); A61K 39/395 (2013.01); B05B 5/025 (2013.01)] 10 Claims
 
1. A method of electrospraying an aqueous first liquid comprising aa protein and (ii) a carbohydrate, a salt, or a combination thereof to form droplets and evaporating the aqueous first liquid to produce particles from the droplets, wherein the carbohydrate, salt, or the combination thereof is observed at the surface of the particles in large quantities; and
wherein the protein in the particles has 0.5 to 1.0 activity per unit.