US 11,654,097 B2
Peptide having activities of skin whitening and uses thereof
Yongji Chung, Gunpo-si (KR); Eun Mi Kim, Yongin-si (KR); Eung Ji Lee, Anyang-si (KR); and Jan Di Kim, Seoul (KR)
Assigned to CAREGEN CO., LTD., Anyang-si (KR)
Appl. No. 16/625,865
Filed by CAREGEN CO., LTD., Anyang-si (KR)
PCT Filed Oct. 10, 2019, PCT No. PCT/KR2019/013266
§ 371(c)(1), (2) Date Mar. 11, 2020,
PCT Pub. No. WO2021/033831, PCT Pub. Date Feb. 25, 2021.
Claims priority of application No. 10-2019-0101880 (KR), filed on Aug. 20, 2019.
Prior Publication US 2022/0183949 A1, Jun. 16, 2022
Int. Cl. A61K 38/00 (2006.01); A61K 8/64 (2006.01); A61Q 19/02 (2006.01); C07K 7/06 (2006.01); A61P 17/02 (2006.01)
CPC A61K 8/64 (2013.01) [A61Q 19/02 (2013.01); C07K 7/06 (2013.01)] 18 Claims
1. A peptide consisting of the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, optionally wherein the N- or C-terminus of the peptide is modified,
wherein the peptide exhibits any one or more characteristic selected from the group consisting of:
(a) inhibition of melanin production;
(b) inhibition of tyrosinase activity; and
(c) inhibition of Ras-related protein Rab-27a (Rab27a), Melanophilin (Mlph), Myosin Heavy chain 12 (myosin VA), Melanocyte Inducing Transcription Factor (MITF), tyrosinase, or Tyrosinase Related Protein-1 (TRP1) expression.