US 11,654,094 B2
Composition comprising benzoic acid amide compound and cyclodextrin solubilizing agent
Chang-geun Yi, Yongin-si (KR); Suil Kim, Yongin-si (KR); Sung Il Park, Yongin-si (KR); and Hong-ju Shin, Yongin-si (KR)
Assigned to AMOREPACIFIC CORPORATION, Seoul (KR)
Appl. No. 16/499,729
Filed by AMOREPACIFIC CORPORATION, Seoul (KR)
PCT Filed Mar. 26, 2018, PCT No. PCT/KR2018/003536
§ 371(c)(1), (2) Date Sep. 30, 2019,
PCT Pub. No. WO2018/182257, PCT Pub. Date Oct. 4, 2018.
Claims priority of application No. 10-2017-0042192 (KR), filed on Mar. 31, 2017.
Prior Publication US 2021/0093532 A1, Apr. 1, 2021
Int. Cl. A61K 8/42 (2006.01); A61K 8/02 (2006.01); A61K 8/19 (2006.01); A61K 8/31 (2006.01); A61K 8/34 (2006.01); A61K 8/37 (2006.01); A61K 8/41 (2006.01); A61K 8/67 (2006.01); A61K 8/73 (2006.01); A61K 8/81 (2006.01); A61K 8/92 (2006.01); A61Q 5/12 (2006.01); A61Q 19/00 (2006.01)
CPC A61K 8/42 (2013.01) [A61K 8/0212 (2013.01); A61K 8/19 (2013.01); A61K 8/31 (2013.01); A61K 8/34 (2013.01); A61K 8/345 (2013.01); A61K 8/375 (2013.01); A61K 8/41 (2013.01); A61K 8/678 (2013.01); A61K 8/73 (2013.01); A61K 8/738 (2013.01); A61K 8/8147 (2013.01); A61K 8/92 (2013.01); A61K 8/922 (2013.01); A61Q 5/12 (2013.01); A61Q 19/007 (2013.01)] 18 Claims
 
1. A composition for external application to the skin comprising:
a solute which is 5-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxy-benzoic acid amide, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof; and
a first solubilizer which is cyclodextrin,
wherein the cyclodextrin comprises hydroxypropyl-β-cyclodextrin and γ-cyclodextrin at a weight ratio of 1:0.1 to 10, and
wherein the weight ratio of the solute to the first solubilizer is 1:1 to 20.