	US 12,304,963 B2
	Antibody complex and uses thereof
Valentina Fiori, Fano (IT); Sabrina Dominici, Fermignano (IT); Diego Moricoli, Fano (IT); Maria Elena Laguardia, Colli Al Metauro (IT); Cosimo Damiano Carbonella, Fano (IT); and Maria Cristina Balducci, Fano (IT)
Assigned to DIATHEVA S.R.L., Cartoceto (IT)
Appl. No. 15/734,775
Filed by DIATHEVA S.R.L., Cartoceto (IT)
PCT Filed Jun. 3, 2019, PCT No. PCT/IB2019/054571 § 371(c)(1), (2) Date Dec. 3, 2020, PCT Pub. No. WO2019/234580, PCT Pub. Date Dec. 12, 2019.
Claims priority of application No. 102018000005991 (IT), filed on Jun. 4, 2018; and application No. 102018000005993 (IT), filed on Jun. 4, 2018.
Prior Publication US 2021/0230292 A1, Jul. 29, 2021
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 35/02 (2006.01)

CPC C07K 16/2896 (2013.01) [A61P 35/02 (2018.01); A61K 2039/505 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01)]

17 Claims

1. An isolated IgG type immunoglobulin capable of recognizing and binding an epitope of the extracellular domain of the human protein CD99, wherein said immunoglobulin comprises at least two variable regions capable of recognizing and binding an epitope of the extracellular domain of the human protein CD99 characterized by an amino acid sequence comprising SEQ ID NO: 21, said at least two variable regions each comprising:

a heavy variable chain (VH) characterized by a CDR3 comprising SEQ ID NO: 1 and

a light variable chain (VL) characterized by a CDR3 comprising SEQ ID NO: 2 wherein:

(1) said VH chain comprises a CDR1 region and a CDR2 region characterized by an amino acid sequence comprising, respectively, SEQ ID NO: 3 and 4 and

(2) said VL chain comprises a CDR1 region and a CDR2 region characterized by an amino acid sequence comprising, respectively, SEQ ID NO: 5 and 6.