	US 12,304,948 B2
	Fully humanized anti-platelet factor 4 antibodies that treat heparin-induced thrombocytopenia
Mark I. Greene, Penn Valley, PA (US); Zheng Cai, Wynnewood, PA (US); Zhiqiang Zhu, Philadelphia, PA (US); and Douglas B. Cines, Wynnewood, PA (US)
Assigned to THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US)
Filed by THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US)
Filed on Nov. 29, 2022, as Appl. No. 18/071,057.
Application 18/071,057 is a continuation of application No. 16/611,613, granted, now 11,524,999, previously published as PCT/US2018/032213, filed on May 11, 2018.
Claims priority of provisional application 62/505,303, filed on May 12, 2017.
Prior Publication US 2023/0265180 A1, Aug. 24, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/24 (2006.01); A61K 31/702 (2006.01); A61K 31/727 (2006.01); C12N 15/85 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01)

CPC C07K 16/24 (2013.01) [A61K 31/702 (2013.01); A61K 31/727 (2013.01); C12N 15/85 (2013.01); A61K 38/00 (2013.01); A61K 39/39533 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)]

18 Claims

1. A polynucleotide encoding a light chain of an antibody, or antigen-binding fragment thereof, that immunospecifically binds to platelet factor 4 (PF4), wherein the light chain or antigen-binding fragment thereof comprises a light chain CDR and framework region comprising the amino acid sequence of SEQ ID NO: 4.