US 12,304,941 B2
Suppression of cytokine release syndrome in chimeric antigen receptor cell therapy
John DiPersio, St. Louis, MO (US); Matthew Cooper, St. Louis, MO (US); and Alun Carter, St. Louis, MO (US)
Assigned to Washington University, St. Louis, MO (US)
Filed by Washington University, St. Louis, MO (US)
Filed on May 17, 2022, as Appl. No. 17/746,645.
Application 17/746,645 is a continuation of application No. 16/428,362, filed on May 31, 2019, abandoned.
Claims priority of provisional application 62/679,597, filed on Jun. 1, 2018.
Prior Publication US 2023/0074186 A1, Mar. 9, 2023
Int. Cl. C07K 14/725 (2006.01); A61K 39/00 (2006.01); A61K 40/11 (2025.01); A61K 40/15 (2025.01); A61K 40/22 (2025.01); A61K 40/31 (2025.01); A61K 40/41 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C12N 15/90 (2006.01)
CPC C07K 14/7051 (2013.01) [A61K 40/11 (2025.01); A61K 40/15 (2025.01); A61K 40/22 (2025.01); A61K 40/31 (2025.01); A61K 40/418 (2025.01); A61K 40/4202 (2025.01); A61K 40/421 (2025.01); A61K 40/4211 (2025.01); A61P 35/00 (2018.01); C07K 16/28 (2013.01); C12N 5/0636 (2013.01); C12N 5/0638 (2013.01); C12N 15/907 (2013.01); A61K 2239/29 (2023.05); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05); C12N 2310/20 (2017.05)] 15 Claims
 
1. A chimeric antigen receptor (CAR)-bearing effector T cell that is deficient in CD40LG.