US 12,304,906 B2
Method for preparing lurasidone hydrochloride
Yikai Zhang, Shanghai (CN); Junzheng Huang, Shanghai (CN); Hao Lu, Shanghai (CN); Xiaowen Guo, Shanghai (CN); Yafei Jiang, Shanghai (CN); Yuanhai Gao, Shanghai (CN); Luning Huang, Shanghai (CN); Anping Tao, Shanghai (CN); Jianguo An, Shanghai (CN); and Hong Gu, Shanghai (CN)
Assigned to Zhejiang Huahai Pharmaceutical Co., Ltd., Zhejiang (CN); and Shanghai Syncores Technologies Inc. Ltd., Shanghai (CN)
Appl. No. 17/787,369
Filed by ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., Zhejiang (CN); and SHANGHAI SYNCORES TECHNOLOGIES INC. LTD., Shanghai (CN)
PCT Filed Dec. 7, 2020, PCT No. PCT/CN2020/134285
§ 371(c)(1), (2) Date Jun. 20, 2022,
PCT Pub. No. WO2021/129364, PCT Pub. Date Jul. 1, 2021.
Claims priority of application No. 201911346683.5 (CN), filed on Dec. 24, 2019.
Prior Publication US 2023/0037151 A1, Feb. 2, 2023
Int. Cl. C07D 417/08 (2006.01); C07D 417/12 (2006.01)
CPC C07D 417/08 (2013.01) 12 Claims
 
1. A method for preparing lurasidone hydrochloride, comprising:
heating and dissolving lurasidone free base in a mixed solvent of alcoholic solvent and dichloromethane, adding hydrochloric acid solution to carry out a salt-forming reaction; and
cooling, crystallizing, filtering and drying to obtain lurasidone hydrochloride.