US 12,304,894 B2
Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1)
Carlos Enrique Fardella Bello, Santiago (CL); Carlos Fernando Lagos Arévalo, Santiago (CL); Andrea Paola Vecchiola Cárdenas, Santiago (CL); Fidel Alejandro Allende Sanzana, Santiago (CL); Benjamin Manuel Diethelm Varela, Santiago (CL); Gonzalo Ivan Recabarren Gajardo, Santiago (CL); and Pablo Marcelo González Cisterna, Santiago (CL)
Assigned to PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Santiago (CL)
Appl. No. 17/604,194
Filed by PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Santiago (CL)
PCT Filed Apr. 17, 2019, PCT No. PCT/CL2019/050029
§ 371(c)(1), (2) Date Oct. 15, 2021,
PCT Pub. No. WO2020/210922, PCT Pub. Date Oct. 22, 2020.
Prior Publication US 2022/0194909 A1, Jun. 23, 2022
Int. Cl. C07D 271/06 (2006.01); C07D 413/10 (2006.01)
CPC C07D 271/06 (2013.01) [C07D 413/10 (2013.01)] 6 Claims
 
1. A compound of formula (I),

OG Complex Work Unit Chemistry
wherein L1 is CH or nitrogen, provided that if L1 is nitrogen then L1 is different from L3; L2 is carbon or nitrogen, provided that if L2 is nitrogen then R1 is not present; L3 is carbon or nitrogen, provided that if L3 is nitrogen then R2 is not present; R1, R2 and R3 are independently selected from a hydrogen atom, F, Br, Cl, NO2, a linear or branched C1-4 alkyl group, or an OR group, where R is H or a linear or branched C1-4 alkyl group, or a pharmaceutically acceptable salt, solvate or hydrate thereof.