US 12,304,885 B2
Synthesis and purification of CBDA
Randall L. Shearer, Broomfield, CO (US)
Assigned to The Regents of the University of Colorado, a body corporate, Denver, CO (US)
Appl. No. 18/856,957
Filed by The Regents of the University of Colorado, Denver, CO (US)
PCT Filed Apr. 20, 2023, PCT No. PCT/US2023/019207
§ 371(c)(1), (2) Date Oct. 15, 2024,
PCT Pub. No. WO2023/205298, PCT Pub. Date Oct. 26, 2023.
Claims priority of provisional application 63/363,252, filed on Apr. 20, 2022.
Prior Publication US 2025/0115542 A1, Apr. 10, 2025
Int. Cl. C07C 51/573 (2006.01)
CPC C07C 51/573 (2013.01) 29 Claims
 
1. A method for the synthesis and purification of cannabidiolic acid (CBDA) comprising the steps of:
dissolving cannabidiol (CBD) in acetonitrile;
adding 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to the dissolved CBD to form a first reaction mixture;
incubating the first reaction mixture at 15 to 25° C. under a pressure of 24 to 36 bar carbon dioxide for about 18 to about 30 hours to form a complex between DBU and CBD;
mixing the DBU-CBD complex with anhydrous magnesium sulfate to form a second reaction mixture comprising Mg(CBDA)2; and
precipitating Mg(CBDA)2 from the second reaction mixture using normal pentane to form a metal salt of CBD.