CPC C07C 51/573 (2013.01) | 29 Claims |
1. A method for the synthesis and purification of cannabidiolic acid (CBDA) comprising the steps of:
dissolving cannabidiol (CBD) in acetonitrile;
adding 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to the dissolved CBD to form a first reaction mixture;
incubating the first reaction mixture at 15 to 25° C. under a pressure of 24 to 36 bar carbon dioxide for about 18 to about 30 hours to form a complex between DBU and CBD;
mixing the DBU-CBD complex with anhydrous magnesium sulfate to form a second reaction mixture comprising Mg(CBDA)2; and
precipitating Mg(CBDA)2 from the second reaction mixture using normal pentane to form a metal salt of CBD.
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