US 12,304,881 B2
Trientine tetrahydrochloride and a method of preparation and a pharmaceutical composition thereof
Cherng-Yih Perng, Hsinchu County (TW); Ming-Ren Liang, Taoyuan (TW); Yu-Chen Lin, Zhubei (TW); and Tai-Yun Feng, Taoyuan (TW)
Assigned to YU-JET CO., LTD, Taipei (TW)
Filed by Yu-Jet Co., Ltd., Taipei (TW)
Filed on Feb. 22, 2023, as Appl. No. 18/172,875.
Claims priority of application No. 111106476 (TW), filed on Feb. 23, 2022.
Prior Publication US 2023/0339842 A1, Oct. 26, 2023
Int. Cl. C07C 211/14 (2006.01); C07C 209/90 (2006.01)
CPC C07C 211/14 (2013.01) [C07C 209/90 (2013.01); C07B 2200/13 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method of preparation of trientine tetrahydrochloride crystals, comprising:
step 1: adding an anti-solvent at a feeding temperature into a trientine tetrahydrochloride solution and stirring for crystallization;
wherein the feeding temperature ranges from 50° C. to 75° C. and the anti-solvent is an alcohol solvent,
wherein the stirring is made for a duration of at least one hour at a temperature ranging from 5° C. to 25° C.,
wherein the method does not require a use of seed crystals, and
wherein the trientine tetrahydrochloride crystals feature X-Ray Powder Diffraction (XRPD) peaks detected at 21.9, 24.8, 25.2, 28.0 and 35.6±0.1° 2θ.