US 12,304,151 B2
3D printed biodegradable implants
Shulamit Levenberg, Moreshet (IL); and Ben Kaplan, Kiryat Tivon (IL)
Assigned to TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, Haifa (IL)
Filed by TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, Haifa (IL)
Filed on Aug. 25, 2021, as Appl. No. 17/411,373.
Application 17/411,373 is a continuation of application No. PCT/IL2020/050212, filed on Feb. 25, 2020.
Claims priority of provisional application 62/809,793, filed on Feb. 25, 2019.
Prior Publication US 2021/0379838 A1, Dec. 9, 2021
Int. Cl. B29C 64/40 (2017.01); A61B 17/11 (2006.01); A61F 2/00 (2006.01); A61F 2/08 (2006.01); B29L 31/00 (2006.01); B33Y 10/00 (2015.01); B33Y 50/00 (2015.01); B33Y 80/00 (2015.01)
CPC B29C 64/40 (2017.08) [A61F 2/0077 (2013.01); B33Y 10/00 (2014.12); B33Y 50/00 (2014.12); B33Y 80/00 (2014.12); A61B 17/1128 (2013.01); A61F 2002/0081 (2013.01); A61F 2002/0086 (2013.01); A61F 2002/0894 (2013.01); A61F 2230/0069 (2013.01); A61F 2240/002 (2013.01); B29K 2995/0056 (2013.01); B29L 2031/7532 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for making an implant scaffold, comprising:
a. printing a 3D template comprising parallel linear structures aligned along a longitudinal axis of said 3D template; wherein the 3D template has a shape of a lesion site;
b. contacting said 3D template with a solution comprising a polymeric precursor, thereby filling a space between the parallel linear structures in said 3D template;
c. evaporating said solution, thereby obtaining an implant scaffold; and
d. dissolving said 3D template; wherein said step a. comprises:
printing a first layer comprising at least two linear anchors aligned along a transversal axis of said 3D template; and
printing a second layer of said parallel linear structures, wherein each of the parallel linear structures bridges the at least two linear anchors.