US 12,303,896 B2
Biological fluid filtration system
Jayant Parthasarathy, Excelsior, MN (US)
Assigned to Astrin Biosciences, Inc., St. Paul, MN (US)
Filed by Astrin Biosciences, Inc., Excelsior, MN (US)
Filed on Mar. 19, 2021, as Appl. No. 17/206,471.
Application 17/206,471 is a continuation of application No. 17/162,450, filed on Jan. 29, 2021.
Claims priority of provisional application 62/968,476, filed on Jan. 31, 2020.
Prior Publication US 2021/0237074 A1, Aug. 5, 2021
Int. Cl. B01L 3/00 (2006.01); B01D 46/00 (2022.01); B01D 46/24 (2006.01); B01D 46/52 (2006.01); B01D 46/64 (2022.01); B01D 46/70 (2022.01); B01D 53/78 (2006.01)
CPC B01L 3/502753 (2013.01) [B01D 46/0013 (2013.01); B01D 46/0028 (2013.01); B01D 46/2414 (2013.01); B01D 46/522 (2013.01); B01D 46/64 (2022.01); B01D 46/70 (2022.01); B01D 53/78 (2013.01); B01L 3/502715 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0681 (2013.01)] 22 Claims
 
1. A method of testing a drug ex vivo on a biological fluid, comprising the steps of: receiving the biological fluid by a fluid filtration device, wherein the fluid filtration device includes an optical scanner comprising a digital holographic microscope, a control unit in communication with the optical scanner, wherein the control unit is configured to receive scanned data from the optical scanner and to compare the scanned data to reference data, wherein the reference data comprise one or more characteristics of a healthy cell; and wherein the control unit is configured to recognize the one or more characteristics of the healthy cell within the scanned data, a first outlet and a second outlet, wherein the fluid filtration device is adapted to receive the biological fluid and generate the scanned data relating to the biological fluid within the fluid receiving device using the optical scanner; separating a first subset of constituents and a second subset of constituents from the biological fluid by the fluid filtration device, wherein the first subset of constituents is determined to include an undesirable constituent using the scanned data; directing the first subset of constituents through the first outlet of the fluid filtration device; directing the second subset of constituents through the second outlet of the fluid filtration device; and testing the drug on the first subset of constituents.