US 12,303,870 B2
Compositions and methods relating to molecular cerium-oxide nanoclusters
George Christou, Gainesville, FL (US); and Kylie J. Mitchell, Pennington, NJ (US)
Assigned to University of Florida Research Foundation, INC., Gainesville, FL (US)
Filed by University of Florida Research Foundation, Inc., Gainesville, FL (US)
Filed on Nov. 17, 2021, as Appl. No. 17/528,678.
Application 17/528,678 is a continuation of application No. 16/467,088, granted, now 11,207,663, previously published as PCT/US2017/064890, filed on Dec. 6, 2017.
Claims priority of provisional application 62/579,217, filed on Oct. 31, 2017.
Claims priority of provisional application 62/430,484, filed on Dec. 6, 2016.
Prior Publication US 2022/0072512 A1, Mar. 10, 2022
Int. Cl. B01J 23/10 (2006.01); A61K 33/244 (2019.01); A61P 39/06 (2006.01); C01F 17/235 (2020.01); C01F 17/30 (2020.01)
CPC B01J 23/10 (2013.01) [A61K 33/244 (2019.01); A61P 39/06 (2018.01); C01F 17/235 (2020.01); C01F 17/30 (2020.01); C01P 2002/77 (2013.01); C01P 2004/64 (2013.01)] 9 Claims
 
1. A method of treating oxidative stress in a subject in need thereof, comprising:
delivering, to a subject in need thereof, a pharmaceutical composition, wherein the pharmaceutical composition includes a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier, to treat the oxidative stress,
wherein the compound comprises one or more molecular cerium-oxide nanocluster with cerium nuclearity of from 19 to 100 and having the formula [CexOy(OH)w(H2O)l(RCO2)z(L)m]n, CexOy(OH)w(H2O)l(RPO2)z(L)m]n or [CexOy(OH)w(H2O)l(RPO3)z(L)m]n, wherein x is from 19 to 100, wherein y is an integer number greater than 0, wherein l, m, n, w, z are 0 or an integer number, wherein R is selected from the group consisting of phenyl (Ph), CH3, CH3CH2, an aromatic group, a polyaromatic group, a substituted phenyl, a polyphenyl group, a linear or branched aliphatic groups, a substituted linear or branched aliphatic group, a linear or branched alicyclic group, and combinations thereof, wherein L is one or more neutral organic molecules, wherein the molecular cerium-oxide nanocluster composition has a ratio of Ce3+/Ce4+ of from 0.01 to 0.5.