US 12,303,693 B2
Systems and methods for controlling operation of an implanted neurostimulation system based on a mapping of episode durations and seizure probability biomarkers
Sharanya Arcot Desai, Sunnyvale, CA (US); and David A. Greene, Fort Wayne, IN (US)
Assigned to NeuroPace, Inc., Mountain View, CA (US)
Filed by NeuroPace, Inc., Mountain View, CA (US)
Filed on Mar. 30, 2022, as Appl. No. 17/709,227.
Claims priority of provisional application 63/312,429, filed on Feb. 22, 2022.
Claims priority of provisional application 63/170,018, filed on Apr. 2, 2021.
Prior Publication US 2022/0314002 A1, Oct. 6, 2022
Int. Cl. A61N 1/36 (2006.01); A61B 5/00 (2006.01); A61N 1/05 (2006.01); A61N 1/372 (2006.01); G06N 3/044 (2023.01); G06N 3/045 (2023.01); G06N 3/047 (2023.01); G06N 20/20 (2019.01); G16H 50/20 (2018.01)
CPC A61N 1/36139 (2013.01) [A61B 5/0006 (2013.01); A61B 5/0031 (2013.01); A61B 5/4064 (2013.01); A61B 5/4094 (2013.01); A61B 5/4848 (2013.01); A61B 5/7267 (2013.01); A61N 1/0526 (2013.01); A61N 1/0529 (2013.01); A61N 1/36064 (2013.01); A61N 1/37247 (2013.01); G06N 3/044 (2023.01); G06N 3/045 (2023.01); G06N 3/047 (2023.01); G06N 20/20 (2019.01); G16H 50/20 (2018.01)] 19 Claims
OG exemplary drawing
 
1. A method of controlling operation of an implanted neurostimulation system configured to sense episodes of electrographic events and determine durations of episodes, the method comprising:
mapping durations of electrographic events sensed by the implanted neurostimulation system with seizure probability biomarkers derived from records of the electrographic events to create a mapping function; and
for each of one or more operations of the implanted neurostimulation system:
selecting a seizure probability biomarker having a value desired for the operation,
selecting a duration mapped to the selected seizure probability biomarker, and
programming the duration into a control module of the implanted neurostimulation system as a programmed parameter that triggers the operation by the implanted neurostimulation system.