US 12,303,621 B2
Use of self-assembled alkylsilane coatings for drug delivery applications
Elia Beniash, Pittsburgh, PA (US); and Avinash Patil, Pittsburgh, PA (US)
Assigned to UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US)
Filed by UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US)
Filed on Jan. 13, 2023, as Appl. No. 18/096,736.
Application 18/096,736 is a continuation of application No. 16/634,186, granted, now 11,559,612, previously published as PCT/US2018/044307, filed on Jul. 30, 2018.
Claims priority of provisional application 62/538,127, filed on Jul. 28, 2017.
Prior Publication US 2023/0166012 A1, Jun. 1, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/16 (2006.01); A61K 31/352 (2006.01); A61K 31/65 (2006.01); A61L 29/14 (2006.01); A61L 29/16 (2006.01); A61L 31/14 (2006.01)
CPC A61L 31/16 (2013.01) [A61K 31/352 (2013.01); A61K 31/65 (2013.01); A61L 29/148 (2013.01); A61L 29/16 (2013.01); A61L 31/148 (2013.01)] 7 Claims
 
1. A medical implant device, comprising:
a substrate composed of a material selected from the group consisting of magnesium and magnesium alloy having an outer surface;
a thin film, self-assembled coating having a laminar structure comprising multilayers, applied to the outer surface of the substrate, the self-assembled coating comprising:
a coating composition, comprising:
an organic small molecule drug; and
a hybrid amphiphilic alkylsilane consisting of a hydrophobic aliphatic tail with a C4 to C20 aliphatic backbone and a hydrophilic silane head reactive with the substrate, comprising:
a cross-linking agent combined with the alkylsilane;
an aminosilane binding compound combined with the self-assembled coating; and
an active component coupled to the aminosilane binding compound,
wherein the self-assembled coating reduces degradation rate of the substrate, and
wherein a release concentration of the organic small molecule drug from the medical implant device increases incrementally over time.