US 12,303,619 B2
Polymer implants
Patrick H. Ruane, El Dorado Hills, CA (US); Jackie Joe Hancock, Berkeley, CA (US); Koon Kiat Teu, Singapore (SG); Daniel Boon Lim Seet, Singapore (SG); Wei Li Lee, Singapore (SG); and Honglei Wang, Singapore (SG)
Assigned to Foundry Therapeutics, Inc., Menlo Park, CA (US)
Appl. No. 17/250,747
Filed by Foundry Therapeutics, Inc., Menlo Park, CA (US)
PCT Filed Aug. 27, 2019, PCT No. PCT/US2019/048437
§ 371(c)(1), (2) Date Feb. 26, 2021,
PCT Pub. No. WO2020/047013, PCT Pub. Date Mar. 5, 2020.
Claims priority of provisional application 62/723,478, filed on Aug. 28, 2018.
Claims priority of provisional application 62/742,357, filed on Oct. 6, 2018.
Claims priority of provisional application 62/832,429, filed on Apr. 11, 2019.
Claims priority of application No. PCT/US2018/054777 (WO), filed on Oct. 6, 2018.
Prior Publication US 2021/0308338 A1, Oct. 7, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/58 (2006.01); A61L 27/18 (2006.01); A61L 27/54 (2006.01)
CPC A61L 27/58 (2013.01) [A61L 27/18 (2013.01); A61L 27/54 (2013.01); A61L 2300/402 (2013.01); A61L 2300/604 (2013.01); A61L 2430/02 (2013.01)] 20 Claims
 
1. A depot comprising:
a polymer matrix including a polyalphahydroxy acid (AHA) having an acid as a degradation byproduct and a therapeutic agent, wherein the therapeutic agent comprises at least 50% of the total weight of the depot, and wherein at least a portion of the polymer matrix has a volume with a minimum cross-sectional dimension of at least 400 μm before degradation of the AHA begins;
wherein, when implanted in vivo, the depot is configured to release the therapeutic agent such that a plurality of pores are formed in the polymer matrix, and
wherein, when the depot is (a) submerged in aqueous media for a duration sufficient for a molecular weight of the AHA and/or a mass of the polymer matrix to decrease by about 25% to about 75%, and (b) subsequently submerged in a buffer solution and broken up such that an interior region of the depot is in fluid communication with the surrounding buffer solution, a pH of the surrounding buffer solution is within about 0.5 units of the pH of the buffer solution before the depot is placed in the buffer solution.