US 12,303,607 B2
Methods and compositions for modifying mucous membranes
Nicholas L. Abbott, Madison, WI (US); and Christopher J. Murphy, Madison, WI (US)
Filed by Nicholas L. Abbott, Madison, WI (US); and Christopher J. Murphy, Madison, WI (US)
Filed on Aug. 1, 2023, as Appl. No. 18/363,316.
Application 18/363,316 is a continuation of application No. 17/222,089, filed on Apr. 5, 2021, granted, now 11,712,423.
Application 17/222,089 is a continuation of application No. 16/000,147, filed on Jun. 5, 2018, granted, now 10,966,935, issued on Apr. 6, 2021.
Application 16/000,147 is a continuation of application No. 14/908,927, granted, now 9,987,235, issued on Jun. 5, 2018, previously published as PCT/US2014/048391, filed on Jul. 28, 2014.
Claims priority of provisional application 61/861,247, filed on Aug. 1, 2013.
Prior Publication US 2024/0082170 A1, Mar. 14, 2024
Int. Cl. A61K 31/00 (2006.01); A61K 9/00 (2006.01); A61K 9/70 (2006.01); A61K 31/095 (2006.01); A61K 31/375 (2006.01); A61K 31/66 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 31/726 (2006.01); A61K 38/02 (2006.01); A61K 38/05 (2006.01); A61K 38/17 (2006.01); A61K 45/06 (2006.01); A61K 47/42 (2017.01); A61K 48/00 (2006.01)
CPC A61K 9/70 (2013.01) [A61K 9/0014 (2013.01); A61K 9/0034 (2013.01); A61K 9/0043 (2013.01); A61K 9/0048 (2013.01); A61K 9/006 (2013.01); A61K 31/00 (2013.01); A61K 31/095 (2013.01); A61K 31/375 (2013.01); A61K 31/66 (2013.01); A61K 31/70 (2013.01); A61K 31/7088 (2013.01); A61K 31/726 (2013.01); A61K 38/02 (2013.01); A61K 38/05 (2013.01); A61K 38/1735 (2013.01); A61K 45/06 (2013.01); A61K 47/42 (2013.01); A61K 48/0075 (2013.01)] 9 Claims
 
1. A composition for modifying a mucous membrane comprising a first agent that physically interacts or reacts with one or more components of said mucous membrane and/or its intimately associated adherent thin film, a second agent that promotes holding an aqueous component of said mucous membrane in place, and a physiologically acceptable carrier wherein said first agent is a peptide, polypeptide or protein comprising or modified to comprise a click chemistry functionality and said second agent is a mucin or mucin analog.