US 12,303,606 B2
Cariprazine release formulations
Yu Hui, Winston Salem, NC (US); Kevin Yuan, Morganville, NJ (US); and Tian Zhang, Richmond (CA)
Assigned to HALO SCIENCE LLC
Filed by HALO SCIENCE LLC, Morganville, NJ (US)
Filed on Apr. 22, 2022, as Appl. No. 17/727,017.
Application 17/727,017 is a division of application No. 16/714,539, filed on Dec. 13, 2019, granted, now 11,344,503.
Prior Publication US 2022/0241212 A1, Aug. 4, 2022
Int. Cl. A61K 9/50 (2006.01); A61K 9/19 (2006.01); A61K 9/51 (2006.01); A61K 31/495 (2006.01); A61K 47/34 (2017.01)
CPC A61K 9/5089 (2013.01) [A61K 9/19 (2013.01); A61K 9/5084 (2013.01); A61K 9/5153 (2013.01); A61K 9/5192 (2013.01); A61K 31/495 (2013.01); A61K 47/34 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method for producing sustained-release microparticles and nanoparticles, comprising:
dissolving an active agent and one or more biodegradable and biocompatible polymers in a solvent that is not highly soluble in water and has a boiling point below 100° C. to form an organic phase;
quenching the organic phase with a non-ionic water-soluble colloid polymer in water to form a quenched composition;
homogenizing the quenched composition to form an emulsion; and
removing the solvent from the emulsion to form a microparticle, microsphere or nanoparticle,
wherein the active agent is selected from the group consisting of cariprazine, a salt thereof, or a derivative thereof including a derivative salt form thereof.