US 12,303,601 B2
Methods of fabrication of concentrated and homogeneously wetted massive polymers and applications thereof
Richard Dolph Andersen, Berlin (DE); Annette Assogba-Zandt, Berlin (DE); Elena Maltseva, Schöneiche (DE); and Andreas Voigt, Berlin (DE)
Appl. No. 16/753,463
Filed by SolyPlus GmbH, Haselund (DE)
PCT Filed Oct. 9, 2018, PCT No. PCT/IB2018/057789
§ 371(c)(1), (2) Date Apr. 3, 2020,
PCT Pub. No. WO2019/073362, PCT Pub. Date Apr. 18, 2019.
Claims priority of application No. 102017009767.4 (DE), filed on Oct. 12, 2017.
Prior Publication US 2020/0253876 A1, Aug. 13, 2020
Int. Cl. A61K 9/14 (2006.01); A61K 47/36 (2006.01)
CPC A61K 9/146 (2013.01) [A61K 47/36 (2013.01)] 20 Claims
 
1. A method of homogeneously wetting a biopolymer, comprising:
mixing at least one biopolymer in the form of a dry powder, frozen aqueous ice, and optionally at least one active pharmaceutical ingredient, the mixing occurring by mechanical energy input to obtain a homogenous mixture at a temperature below the freezing point of the aqueous ice, wherein the at least one biopolymer and frozen aqueous ice are mixed in a range of about 40-50% biopolymer by mass;
further mixing the homogenous mixture of the at least one biopolymer, frozen aqueous ice, and optionally the at least one active pharmaceutical ingredient, the mixing occurring along with a steady increase of temperature to above the freezing point of the aqueous ice; and then
further kneading and/or mixing to produce a homogeneously wetted biopolymer,
wherein the at least one biopolymer comprises a polysaccharide, hyaluronic acid, sodium hyaluronate, chitosan, alginate, or any combination thereof.