US 12,303,582 B2
Composition for the treatment of nail fungus
Bart Rossel, Merelbeke (BE)
Assigned to Oystershell NV, Merelbeke (BE)
Filed by Oystershell NV, Merelbeke (BE)
Filed on Mar. 25, 2021, as Appl. No. 17/212,380.
Claims priority of application No. 2020/5196 (BE), filed on Mar. 26, 2020.
Prior Publication US 2021/0299022 A1, Sep. 30, 2021
Int. Cl. A61K 8/49 (2006.01); A61K 8/33 (2006.01); A61K 8/36 (2006.01); A61K 8/365 (2006.01); A61K 8/37 (2006.01); A61K 8/81 (2006.01); A61K 9/00 (2006.01); A61K 31/19 (2006.01); A61K 47/08 (2006.01); A61K 47/14 (2017.01); A61K 47/22 (2006.01); A61K 47/32 (2006.01); A61Q 3/02 (2006.01)
CPC A61K 8/4986 (2013.01) [A61K 8/33 (2013.01); A61K 8/36 (2013.01); A61K 8/365 (2013.01); A61K 8/37 (2013.01); A61K 8/4973 (2013.01); A61K 8/8147 (2013.01); A61K 9/0014 (2013.01); A61K 31/19 (2013.01); A61K 47/08 (2013.01); A61K 47/14 (2013.01); A61K 47/22 (2013.01); A61K 47/32 (2013.01); A61Q 3/02 (2013.01)] 20 Claims
 
1. A method for treatment of a fungal infection, the method comprising: applying a composition to a nail of a person to be treated wherein said nail has a fungal infection and a resulting discoloration, said composition including:
at least one physiologically acceptable carboxylic acid capable of reducing the pH in the nail of the treated person below 4.0,
a physiologically acceptable carrier comprising at least one C1-C4 alkyl ester of lactic acid and optionally at least one additional volatile solvent,
a film-forming polymer provided in a quantity of 0.05 to 10% by weight of the composition; wherein the film-forming polymer comprises ammonium methacrylate copolymer; and at least one physiologically acceptable fluorescent whitening agent comprising 2,5-bis (5-tert-butyl-benzoxazol-2-yl) thiophene (FWA-184),
wherein, upon evaporation of the physiologically acceptable carrier, the applied composition forms a solidified film layer in contact with the nail;
wherein the applied composition treats the fungal infection and reduces the appearance of the resulting discoloration, and
wherein the applied composition has a whitening effect.