US 12,303,572 B2
Ascorbate formulations and methods of use as contrast agents
Christopher David Lascola, Durham, NC (US)
Assigned to Duke University, Durham, NC (US)
Filed by Duke University, Durham, NC (US)
Filed on Jul. 28, 2021, as Appl. No. 17/443,863.
Application 17/443,863 is a continuation of application No. 16/365,939, filed on Mar. 27, 2019, granted, now 11,083,803, issued on Aug. 10, 2021.
Application 16/365,939 is a continuation of application No. 15/461,759, filed on Mar. 17, 2017, granted, now 10,286,089, issued on May 14, 2019.
Application 15/461,759 is a continuation of application No. PCT/US2016/054481, filed on Sep. 29, 2016.
Claims priority of provisional application 62/234,986, filed on Sep. 30, 2015.
Claims priority of provisional application 62/291,138, filed on Feb. 4, 2016.
Prior Publication US 2021/0353780 A1, Nov. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 49/06 (2006.01); A61B 5/00 (2006.01); A61B 5/055 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 47/02 (2006.01); A61K 47/26 (2006.01); A61K 49/10 (2006.01)
CPC A61K 49/06 (2013.01) [A61B 5/0042 (2013.01); A61B 5/0044 (2013.01); A61B 5/055 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 47/02 (2013.01); A61K 47/26 (2013.01); A61K 49/10 (2013.01)] 29 Claims
 
1. A method of enhancing a magnetic resonance imaging (MRI) image of a body or body region, or an organ or organ region in a subject, comprising:
parenterally administering to said subject in an MRI image-enhancing amount a sterile aqueous composition comprising:
100-600 mM ascorbate; and
100-600 mM sodium, meglumine, or a combination thereof,
wherein said composition comprises a spin-spin exchange catalyst, and wherein said composition has an osmolarity of 200-1400 mOsm/L; and then
generating, by MRI of the subject, an image of said body or body region,
whereby said MRI image in enhanced.