	US 12,303,569 B2
	Lipid nanoparticle compositions and uses thereof
Bin Wu, Lexington, MA (US); Heliang Song, Natick, MA (US); and Victoria Trantow, Natick, MA (US)
Assigned to Cytodigm, Inc., Natick, MA (US)
Filed by CYTODIGM, INC., Natick, MA (US)
Filed on Sep. 10, 2024, as Appl. No. 18/829,557.
Application 18/829,557 is a continuation of application No. PCT/US2023/026541, filed on Jun. 29, 2023.
Claims priority of provisional application 63/356,557, filed on Jun. 29, 2022.
Prior Publication US 2025/0001003 A1, Jan. 2, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 48/00 (2006.01); A61K 9/51 (2006.01); A61K 38/46 (2006.01); C12N 15/113 (2010.01); C12N 15/88 (2006.01)

CPC A61K 48/0033 (2013.01) [A61K 9/5123 (2013.01); A61K 38/465 (2013.01); C12N 15/113 (2013.01); C12N 15/88 (2013.01); C12N 2310/14 (2013.01)]

17 Claims

1. A lipid nanoparticle composition comprising a ganglioside GD3, an ionizable lipid, phospholipid, cholesterol, and a nucleic acid, said lipid nanoparticle has an average particle size of 30-200 nm ; wherein the lipid nanoparticle does not comprise a PEG-lipid.