US 12,303,568 B2
Cerium oxide nanocomplex and a composition for preventing or treating peritonitis comprising the same
Ju Hee Han, Seoul (KR); and Sumin Lee, Seoul (KR)
Assigned to Cenyx Biotech Inc., Seoul (KR)
Filed by Cenyx Biotech Inc., Seoul (KR)
Filed on Sep. 22, 2022, as Appl. No. 17/950,499.
Claims priority of provisional application 63/247,563, filed on Sep. 23, 2021.
Prior Publication US 2023/0099752 A1, Mar. 30, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/69 (2017.01); A61P 1/00 (2006.01)
CPC A61K 47/6929 (2017.08) [A61K 47/6923 (2017.08); A61P 1/00 (2018.01)] 11 Claims
 
1. A cerium oxide nanocomplex comprising:
(a) a core layer of cerium oxide nanoparticles;
(b) an inner layer including a polymer represented by the following Formula 1 and a multifunctional ligand represented by the following Formula 2:

OG Complex Work Unit Chemistry
wherein R1 is hydrogen, R2 is oxygen, custom character represents a single bond or a double bond, l is 1, and m is an integer of 100 to 1000;

OG Complex Work Unit Chemistry
wherein n is an integer of 3 to 7; and
(c) an outer layer comprising a polyglutamic acid (PGA).