US 12,303,566 B2
Immunostimulatory compositions and methods of use thereof
Darrell Irvine, Arlington, MA (US); and Haipeng Liu, Malden, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
Filed on Mar. 5, 2021, as Appl. No. 17/193,999.
Application 14/790,432 is a division of application No. 13/844,075, filed on Mar. 15, 2013, granted, now 9,107,904, issued on Aug. 18, 2015.
Application 17/193,999 is a continuation of application No. 16/040,181, filed on Jul. 19, 2018, granted, now 10,953,105.
Application 16/040,181 is a continuation of application No. 14/790,432, filed on Jul. 2, 2015, granted, now 10,029,016, issued on Jul. 24, 2018.
Claims priority of provisional application 61/620,518, filed on Apr. 5, 2012.
Prior Publication US 2021/0187112 A1, Jun. 24, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/64 (2017.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/21 (2006.01); A61K 39/39 (2006.01); A61K 47/54 (2017.01)
CPC A61K 47/645 (2017.08) [A61K 39/0005 (2013.01); A61K 39/0011 (2013.01); A61K 39/12 (2013.01); A61K 39/21 (2013.01); A61K 39/39 (2013.01); A61K 47/542 (2017.08); A61K 47/543 (2017.08); A61K 47/643 (2017.08); A61K 47/6455 (2017.08)] 21 Claims
 
1. An amphiphilic albumin-binding conjugate comprising
(a) a lipid component;
(b) an optional polar component; and
(c) a ligand for a pattern recognition receptor;
wherein the ligand for a pattern recognition receptor is bound directly to the lipid or is bound to the lipid via a linker,
wherein the conjugate is sufficiently soluble that the lipid binds to albumin under physiological conditions, and
wherein a plurality of the conjugates can spontaneously form micelles in aqueous solution.