	US 12,303,564 B2
	Composite chitosan-tannin-active agent compositions and methods of making and using same
Jess Reed, Verona, WI (US); and Christian Krueger, Cambridge, WI (US)
Assigned to Wisconsin Alumni Research Foundation, Madison, WI (US)
Filed by WISCONSIN ALUMNI RESEARCH FOUNDATION, Madison, WI (US)
Filed on Nov. 9, 2021, as Appl. No. 17/522,334.
Claims priority of provisional application 63/163,322, filed on Mar. 19, 2021.
Prior Publication US 2022/0296720 A1, Sep. 22, 2022
Int. Cl. A61K 47/36 (2006.01); A61K 9/00 (2006.01); A61K 9/70 (2006.01); A61K 31/4045 (2006.01); A61K 31/661 (2006.01); A61K 31/7016 (2006.01); A61K 47/22 (2006.01)

CPC A61K 47/36 (2013.01) [A61K 9/006 (2013.01); A61K 31/4045 (2013.01); A61K 31/661 (2013.01); A61K 31/7016 (2013.01); A61K 47/22 (2013.01); A61K 9/70 (2013.01)]

20 Claims

1. A composite composition comprising chitosan lacking lactate moieties, condensed tannin lacking sulfonate moieties, and an active agent, wherein:

the chitosan lacking lactate moieties has a number average molecular weight of from 125 kDa to 500 kDa;

the tannin lacking sulfonate moieties has a weight average molecular weight of from 100 Da to 10,000 Da;

the chitosan lacking lactate moieties and the tannin lacking sulfonate moieties are present in a weight ratio of the chitosan lacking lactate moieties-to-the tannin lacking sulfonate moieties of from 85:15 to 99:1;

the active agent is selected from the group consisting of serotonin, melatonin, psilocybin, and any combination thereof;

the active agent is present in the composition in an amount of from 0.001 mg to 500 mg;

the composition is in a form of a film; and

the film dissolves in saliva within 4.5 minutes.