US 12,303,560 B2
Recombinant bovine immunodeficiency virus-like particles comprising an influenza HA transmembrane domain and C-terminus
Peter Pushko, Frederick, MD (US); and Irina Tretyakova, Frederick, MD (US)
Assigned to MEDIGEN, INC., Frederick, MD (US)
Filed by MEDIGEN, INC., Frederick, MD (US)
Filed on Jan. 12, 2023, as Appl. No. 18/153,667.
Application 18/153,667 is a division of application No. 15/741,443, granted, now 11,576,965, previously published as PCT/US2016/040838, filed on Jul. 1, 2016.
Claims priority of provisional application 62/188,084, filed on Jul. 2, 2015.
Prior Publication US 2023/0310579 A1, Oct. 5, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/21 (2006.01); A61K 39/12 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01); C12N 15/866 (2006.01); G01N 33/53 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/21 (2013.01) [A61K 39/12 (2013.01); C12N 7/00 (2013.01); C12N 7/045 (2013.01); C12N 15/866 (2013.01); G01N 33/53 (2013.01); A61K 2039/5258 (2013.01); C12N 2740/14034 (2013.01); C12N 2740/15023 (2013.01); C12N 2740/15051 (2013.01); C12N 2740/16023 (2013.01); C12N 2760/16134 (2013.01)] 30 Claims
 
1. A bovine immunodeficiency virus gag virus like particle (“Bgag VLP”) comprising
an Influenza HA transmembrane domain and C Terminus (“TMCT”) and
a heterologous antigen,
wherein the heterologous antigen is functionally connected to the HA TMCT.