US 12,303,546 B2
Antimicrobial compositions and methods of use thereof
Vincent C. Bond, Stone Mountain, GA (US); Michael Powell, Douglasville, GA (US); Ming Bo Huang, Atlanta, GA (US); Syed Ali, New Iberia, LA (US); and Martin N. Shelton, Mountlake Terrace, WA (US)
Assigned to MOREHOUSE SCHOOL OF MEDICINE, Atlanta, GA (US)
Filed by MOREHOUSE SCHOOL OF MEDICINE, Atlanta, GA (US)
Filed on Apr. 4, 2022, as Appl. No. 17/657,885.
Application 17/657,885 is a continuation of application No. 16/947,808, filed on Aug. 18, 2020, granted, now 11,304,991.
Application 16/947,808 is a continuation of application No. 16/241,316, filed on Jan. 7, 2019, abandoned.
Application 16/241,316 is a continuation of application No. 15/397,359, filed on Jan. 3, 2017, granted, now 10,206,974, issued on Feb. 19, 2019.
Application 15/397,359 is a continuation of application No. 14/156,119, filed on Jan. 15, 2014, granted, now 9,556,224, issued on Jan. 31, 2017.
Application 14/156,119 is a continuation of application No. 13/267,977, filed on Oct. 7, 2011, granted, now 8,669,226, issued on Mar. 11, 2014.
Prior Publication US 2022/0249600 A1, Aug. 11, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/16 (2006.01); A61K 38/08 (2019.01); A61K 45/06 (2006.01); A61K 47/60 (2017.01); C07K 7/06 (2006.01); C12N 7/00 (2006.01)
CPC A61K 38/162 (2013.01) [A61K 38/08 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); C07K 7/06 (2013.01); C12N 7/00 (2013.01); C12N 2740/16032 (2013.01); Y02A 50/30 (2018.01)] 5 Claims
 
1. A pharmaceutical composition for treating a gram positive or gram negative bacterial infection, comprising: (1) an antimicrobial peptide comprising an antimicrobial domain comprising the amino acid sequence of SEQ ID NO: 3 bound at the N- or C-terminus to a cell penetrating peptide (CPP) domain; and (2) a pharmaceutically acceptable carrier; wherein the CPP is one selected from the group consisting of HIV TAT49-.s7 peptide, HIV TAT 48-60 peptide, low molecular weight protamine (LMWP) peptide; Pep-1; Antp43-58 peptide, MPG (HIV Gp41-SV40 NLS), SAP, MPG R9, MAP, K-FGF, Penetratin, Buforin II, Transportan, Ku70, Prion, pVEC, Pep-1-K, Pep-7, HN-1, TP10, and CP26.