US 12,303,531 B2
Molecular complex assembly particles comprising bis-R1,R2-dithiocarbamate-metal complex and a ligand, method of preparation and use thereof
Martin Mistrik, Olomouc (CZ); Jiri Bartek, Greve (DK); Zdenek Skrott, Ruzdka (CZ); Petr Dzubak, Brodek u Prerova (CZ); and Marian Hajduch, Moravsky Beroun (CZ)
Assigned to PALACKY UNIVERSITY OLOMOUC, Olomouc (CZ)
Appl. No. 17/282,142
Filed by PALACKY UNIVERSITY OLOMOUC, Olomouc (CZ)
PCT Filed Oct. 8, 2019, PCT No. PCT/EP2019/077222
§ 371(c)(1), (2) Date Apr. 1, 2021,
PCT Pub. No. WO2020/074514, PCT Pub. Date Apr. 16, 2020.
Claims priority of application No. 18199181 (EP), filed on Oct. 8, 2018.
Prior Publication US 2022/0000914 A1, Jan. 6, 2022
Int. Cl. A61K 33/34 (2006.01); A61K 9/16 (2006.01); A61K 47/34 (2017.01)
CPC A61K 33/34 (2013.01) [A61K 9/1635 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A molecular complex assembly particulate form comprising dithiocarbamate-metal compound and at least one ligand, said particulate form being free of organic solvents,
wherein the dithiocarbamate has a formula (R1)(R2)N—CH2S2—, wherein R1 and R2 are the same or different and are independently selected from C1-C8 alkyl, and
wherein the ligands are water-soluble polymers selected from polyhydroxyacids, and stearic acid based polymers.