US 12,303,513 B2
Methods and compositions to treat cancer
Jeffrey A. Whitsett, Cininnati, OH (US); Yutaka Maeda, Cincinnati, OH (US); and Takuya Fukazawa, Okayama (JP)
Assigned to Children's Hospital Medical Center, Cincinnati, OH (US)
Filed by Children's Hospital Medical Center, Cincinnati, OH (US)
Filed on May 2, 2023, as Appl. No. 18/142,308.
Application 16/857,285 is a division of application No. 16/312,478, granted, now 10,668,078, issued on Jun. 2, 2020, previously published as PCT/US2017/044335, filed on Jul. 28, 2017.
Application 18/142,308 is a continuation of application No. 17/308,179, filed on May 5, 2021, granted, now 11,672,806.
Application 17/308,179 is a continuation of application No. 16/857,285, filed on Apr. 24, 2020, granted, now 11,026,950, issued on Jun. 8, 2021.
Claims priority of provisional application 62/367,832, filed on Jul. 28, 2016.
Prior Publication US 2023/0285403 A1, Sep. 14, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/5377 (2006.01); A61K 31/429 (2006.01); A61K 31/4375 (2006.01); A61K 31/4427 (2006.01); A61K 31/444 (2006.01); A61P 35/00 (2006.01)
CPC A61K 31/5377 (2013.01) [A61K 31/429 (2013.01); A61K 31/4375 (2013.01); A61K 31/4427 (2013.01); A61K 31/444 (2013.01); A61P 35/00 (2018.01)] 11 Claims
OG exemplary drawing
 
1. A method of treating lung cancer that expresses midkine (MDK) comprising administering to an individual in need thereof an effective amount of a pharmaceutical composition comprising the compound

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier.