US 12,303,491 B2
Econazole nitrate medical patch and methods of use thereof
David B. Lebo, Warminster, PA (US); and Cong Li, Philadelphia, PA (US)
Assigned to Temple University-Of The Commonwealth System of Higher Education, Philadelphia, PA (US)
Appl. No. 16/488,250
Filed by Temple University-Of The Commonwealth System of Higher Education, Philadelphia, PA (US)
PCT Filed Feb. 28, 2018, PCT No. PCT/US2018/020080
§ 371(c)(1), (2) Date Aug. 23, 2019,
PCT Pub. No. WO2018/160613, PCT Pub. Date Sep. 7, 2018.
Claims priority of provisional application 62/464,483, filed on Feb. 28, 2017.
Prior Publication US 2021/0212994 A1, Jul. 15, 2021
Int. Cl. A61K 31/4174 (2006.01); A61K 9/00 (2006.01); A61K 9/70 (2006.01); A61K 47/10 (2017.01); A61K 47/20 (2006.01)
CPC A61K 31/4174 (2013.01) [A61K 9/0014 (2013.01); A61K 9/7061 (2013.01); A61K 47/10 (2013.01); A61K 47/20 (2013.01)] 13 Claims
 
1. A medicinal patch comprising:
a reservoir layer comprising a pharmaceutical composition comprising an imidazole class antifungal drug and a permeability enhancer; and
a skin adhesive layer comprising an acrylate;
wherein the reservoir layer or the skin adhesive layer further comprises polyvinylpyrrolidone;
wherein neither the reservoir layer nor the skin adhesive layer includes a disintegrant;
wherein the reservoir layer does not comprise a resinous crosslinking agent impregnated with the composition;
wherein the skin adhesive layer does not comprise an imidazole class antifungal drug; and
wherein the surface pH of the medicinal patch is between 4 and 6.