	US 12,303,476 B2
	Compositions and methods of achieving pain relief
Dale G. Brown, Wharton, TX (US); and Ira D. Hill, Austin, TX (US)
Assigned to NeoHack Life Sciences LLC, Austin, TX (US)
Filed by NeoHack Life Sciences LLC, Dallas, TX (US)
Filed on Oct. 25, 2023, as Appl. No. 18/383,606.
Application 18/383,606 is a division of application No. 17/676,339, filed on Feb. 21, 2022, abandoned.
Application 17/676,339 is a continuation in part of application No. 16/408,504, filed on May 10, 2019, abandoned.
Application 16/408,504 is a continuation of application No. PCT/US2018/034296, filed on May 24, 2018.
Claims priority of provisional application 62/522,336, filed on Jun. 20, 2017.
Prior Publication US 2024/0165057 A1, May 23, 2024
Int. Cl. A61K 36/00 (2006.01); A61K 31/015 (2006.01); A61K 31/045 (2006.01); A61K 31/16 (2006.01); A61K 31/164 (2006.01); A61P 23/02 (2006.01)

CPC A61K 31/16 (2013.01) [A61K 31/015 (2013.01); A61K 31/045 (2013.01); A61K 31/164 (2013.01); A61P 23/02 (2018.01)]

20 Claims

1. A method of treating a subject in need of pain relief, the method comprising:

administering to the skin of a subject an effective amount of a composition to relieve a painful condition, the composition comprising: a mixture of spilanthol in the range of 0.1 wt % to 0.5% wt %, pellitorine in the range of 0.05 wt % to 0.2 wt %, beta-caryophyllene in the range of 1 wt % to 3 wt %, and pro-vitamin B5 in the range of 2 wt % to 6 wt %,

wherein the composition is in a topical formulation including cream, gel, or lotion,

wherein the non-vitamin components of the mixture are in an amount of from 0.01 mg to 1000 mg, and

wherein the vitamin component of the mixture is in an amount of from 1.5 mg to 1000 mg.