US 12,303,384 B2
Electrospun heart valves
Jurgen Sander Miedema, Mels (CH); and Martijn Antonius Johannes Cox, Budel (NL)
Assigned to Xeltis AG, Zurich (CH)
Appl. No. 17/618,449
Filed by Xeltis AG, Zurich (CH)
PCT Filed Jun. 26, 2020, PCT No. PCT/EP2020/068151
§ 371(c)(1), (2) Date Dec. 11, 2021,
PCT Pub. No. WO2020/260661, PCT Pub. Date Dec. 30, 2020.
Claims priority of provisional application 62/867,279, filed on Jun. 27, 2019.
Prior Publication US 2022/0346947 A1, Nov. 3, 2022
Int. Cl. A61F 2/24 (2006.01)
CPC A61F 2/2415 (2013.01) [A61F 2/2418 (2013.01); A61F 2210/0004 (2013.01); A61F 2230/0067 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of electrospinning a heart valve having a plurality of leaflets, comprising:
(a) having a conical shaped mandrel with opposite ends both being circular shaped, wherein the conical shaped mandrel has a linear slope angle ranging from 1 to 12.5 degrees, wherein the linear slope is defined between the opposite ends of the conical shaped mandrel;
(b) forming a single conically shaped electrospun scaffold by electrospinning polymers onto the conical shaped mandrel; and
(c) shaping the single conically shaped electrospun scaffold into the heart valve shaped with the plurality of leaflets, wherein the single conically shaped electrospun scaffold remains in one single piece while shaping the plurality leaflets.