US 12,303,280 B2
Method for determining electrical activity of cardiac muscle
Jerzy Stanislaw Janicki, Puszczykowo (PL); and Lukasz Jerzy Janicki, Puszczykowo (PL)
Assigned to PRIMAX MEDICA SP. Z O.O., Puszczykowo (PL)
Appl. No. 17/426,199
Filed by PRIMAX MEDICA SP. Z O.O., Puszczykowo (PL)
PCT Filed Jan. 28, 2020, PCT No. PCT/IB2020/050639
§ 371(c)(1), (2) Date Jul. 28, 2021,
PCT Pub. No. WO2020/157642, PCT Pub. Date Aug. 6, 2020.
Claims priority of application No. 19461508 (EP), filed on Jan. 28, 2019.
Prior Publication US 2022/0175301 A1, Jun. 9, 2022
Int. Cl. A61B 5/366 (2021.01); A61B 5/30 (2021.01); A61B 5/358 (2021.01); A61B 5/36 (2021.01)
CPC A61B 5/366 (2021.01) [A61B 5/30 (2021.01); A61B 5/358 (2021.01); A61B 5/36 (2021.01)] 6 Claims
OG exemplary drawing
 
1. A method for decomposing a resultant electric potential (Vwyp) forming a QRS complex in an electrocardiogram (ECG) into partial potentials corresponding to depolarization of specific areas (/) of a left ventricular muscle (MS), in which decomposition is carried out in such a way that on the basis of a theoretical SFHAM (single fiber based heart activity model) of electrical heart activity, mathematical functions describing changes in the partial potential values are determined, and then their parameters are selected so that superposition of the values of these functions is as close as possible to a resultant potential (Vwyp) measured during an ECG test,
wherein each of the partial potentials is described by two functions: V1,i (t) and V2,i (t), corresponding to the depolarization of a specific area of the left ventricular muscle, each of these functions has negative or positive values and one extremum, wherein a beginning of an emergence of these potentials (t0(1),i and t0(2),i) and their end (tk(1),i and tk(2),i) is considered the time at which the potential value is greater than its arbitrarily set minimum value, and a sum of the values of these potentials determines the electrical activity of the specific area of the left ventricular muscle, the method comprising:
obtaining, from the ECG test, a signal indicative of the electrical heart activity;
obtaining, from the signal, a plurality of electric potential values corresponding to measurements of the electrical heart activity, wherein the plurality of electric potential values includes the partial potential values;
calculating, using the plurality of electrical potential values obtained from the signal, an order of occurrence of extrema of the partial potential values,
wherein the order of occurrence of the extrema is determined from the theoretical SFHAM model of electrical heart activity, and positions of the extrema are determined by, using a computer:
making a series of transformations of the partial potential values for (X Y Z) coordinates in the orthogonal system, comprising rotation of the coordinates in the range (0÷90°) with respect to two selected axes by (α, β) angles,
calculating, for each rotation angle, the positions of extrema of the partial potentials for each of the (XYZ) coordinates, by using deconvolution and convolution, and a low-pass filter with parameters corresponding to the function describing the partial potentials, and then
selecting the angles for which the differences in the positions of extrema for each of the partial potentials in the XYZ system, respectively, are the smallest; and
outputting, using the order of occurrence of the extrema, an analysis of results of the ECG test.