	US 12,302,902 B2
	Antimicrobial compositions, including antimicrobial hydrogels, effective against mature biofilms
Robert DiLuccio, Haymarket, VA (US)
Assigned to CorMedix Inc., Berkeley Heights, NJ (US)
Filed by Cormedix Inc., Berkeley Heights, NJ (US)
Filed on Jan. 3, 2018, as Appl. No. 15/861,159.
Claims priority of provisional application 62/442,775, filed on Jan. 5, 2017.
Prior Publication US 2018/0184656 A1, Jul. 5, 2018
Int. Cl. A01N 43/88 (2006.01); A01N 37/02 (2006.01); C07D 285/18 (2006.01); C08B 37/08 (2006.01); C08J 3/075 (2006.01); C09D 5/14 (2006.01); C09D 5/16 (2006.01); C09D 105/08 (2006.01)

CPC A01N 43/88 (2013.01) [A01N 37/02 (2013.01); C07D 285/18 (2013.01); C08B 37/0072 (2013.01); C08J 3/075 (2013.01); C09D 5/14 (2013.01); C09D 5/16 (2013.01); C09D 105/08 (2013.01); A61L 2400/18 (2013.01)]

5 Claims

1. A method for killing Pseudomonas aeruginosa on at least one surface of a catheter, the method comprising the steps of: (a) providing a bio-film active composition comprising: taurolidine, wherein the concentration of the taurolidine, is 0.5% by weight, 1.0% by weight, 1.5% by weight, or 3.0% by weight of the total weight of the bio-film active composition;

a biofilm-penetrating agent comprising myristic acid, wherein the concentration of the myristic acid is about 1.5% by weight of the total weight of the bio-film active composition; and a base material, wherein the base material comprises a hydrogel comprising hyaluronic acid having a molecular weight of 750 kDa to 1.0 MDa; and

(b) delivering the bio-film active composition to the at least one surface of a catheter in a sufficient amount and for a sufficient period of time to kill Pseudomonas aeruginosa on at least one surface of the catheter.