US 11,982,674 B2
Reagents for quantitative mass spectrometry
Craig Braun, Cambridge, MA (US); Wilhelm Haas, Cambridge, MA (US); Steven P. Gygi, Cambridge, MA (US); Gregory H. Bird, Pelham, NH (US); Loren D. Walensky, Newton, MA (US); Martin Helmut Wuhr, Cambridge, MA (US); and Brian K. Erickson, Cambridge, MA (US)
Assigned to President and Fellows of Harvard College, Cambridge, MA (US); and Dana-Farber Cancer Institute, Inc., Boston, MA (US)
Filed by President and Fellows of Harvard College, Cambridge, MA (US); and Dana-Farber Cancer Institute, Inc., Boston, MA (US)
Filed on Jul. 28, 2021, as Appl. No. 17/387,888.
Application 17/387,888 is a continuation of application No. 15/578,382, granted, now 11,169,155, previously published as PCT/US2016/035819, filed on Jun. 3, 2016.
Claims priority of provisional application 62/170,657, filed on Jun. 3, 2015.
Prior Publication US 2022/0018847 A1, Jan. 20, 2022
Prior Publication US 2023/0132372 A9, Apr. 27, 2023
Int. Cl. C07D 207/46 (2006.01); C07C 237/22 (2006.01); C07K 1/13 (2006.01); C07K 5/02 (2006.01); G01N 33/58 (2006.01); G01N 33/68 (2006.01)
CPC G01N 33/58 (2013.01) [C07C 237/22 (2013.01); C07D 207/46 (2013.01); C07K 1/13 (2013.01); C07K 5/0202 (2013.01); G01N 33/6848 (2013.01); C07B 2200/07 (2013.01); G01N 2458/15 (2013.01)] 10 Claims
 
1. A system comprising a set of mass spectrometry tags, wherein:
each tag of the set is configured to fragment under dissociation conditions in a mass spectrometer to produce at least two reporter ions,
the at least two reporter ions comprise a primary reporter ion and a secondary reporter ion, and
the primary reporter ion is configured to undergo one or more chemical reactions to produce the secondary reporter ion.