US 11,982,667 B2
Platelet aggregation capacity analyzer, analysis method, and analysis system using complex dielectric permittivity
Aya Fuchigami, Tokyo (JP); Seungmin Lee, Tokyo (JP); Yoshihito Hayashi, Tokyo (JP); and Kenzo Machida, Tokyo (JP)
Assigned to SONY CORPORATION, Tokyo (JP)
Appl. No. 17/286,074
Filed by SONY CORPORATION, Tokyo (JP)
PCT Filed Aug. 27, 2019, PCT No. PCT/JP2019/033537
§ 371(c)(1), (2) Date Apr. 16, 2021,
PCT Pub. No. WO2020/084893, PCT Pub. Date Apr. 30, 2020.
Claims priority of application No. 2018-201109 (JP), filed on Oct. 25, 2018.
Prior Publication US 2021/0382036 A1, Dec. 9, 2021
Int. Cl. G01N 33/49 (2006.01); G01N 27/22 (2006.01); G01N 33/50 (2006.01)
CPC G01N 33/4905 (2013.01) [G01N 27/221 (2013.01); G01N 33/5044 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A platelet aggregation capacity analyzer, comprising:
a blood coagulation system-analyzing unit configured to analyze a platelet aggregation capacity of a platelet-containing sample based on first measurement data during a coagulation process with a platelet aggregation inhibitor added to the platelet-containing sample and second measurement data during the coagulation process without a platelet agonist or the platelet aggregation inhibitor added to the platelet-containing sample; and
an output control unit configured to control an output of results analyzed by the blood coagulation system-analyzing unit, wherein
the first measurement data during the coagulation process is about an electrical characteristic which is a complex dielectric permittivity of the platelet-containing sample,
a first feature value for a change in spectrum of the complex dielectric permittivity is used in the blood coagulation system-analyzing unit,
a platelet activation residual rate AR (%) is calculated based on the first feature value extracted from the spectrum of the complex dielectric permittivity of the platelet-containing sample, and
the activation residual rate AR (%) is calculated by following equation (1):

OG Complex Work Unit Math
αdbcm: the first feature value extracted from the spectrum of the complex dielectric permittivity of the platelet-containing sample to be measured,
αmax: a second feature value extracted from the spectrum of the complex dielectric permittivity of the platelet-containing sample with the platelet aggregation inhibitor added,
αmin: a third feature value extracted from the spectrum of the complex dielectric permittivity of the platelet-containing sample without the platelet agonist or the platelet aggregation inhibitor added.
 
10. A platelet aggregation capacity analysis method, comprising:
analyzing a platelet aggregation capacity of a platelet-containing sample based on first measurement data during a coagulation process with a platelet aggregation inhibitor added to the platelet-containing sample and second measurement data during the coagulation process without a platelet agonist or the platelet aggregation inhibitor added to the platelet-containing sample; and
controlling an output of results analyzed for the platelet aggregation capacity of the platelet-containing sample, wherein
the first measurement data during the coagulation process is about an electrical characteristic which is a complex dielectric permittivity of the platelet-containing sample,
a first feature value for a change in spectrum of the complex dielectric permittivity is used in the analyzation of the platelet aggregation capacity of the platelet-containing sample,
a platelet activation residual rate AR (%) is calculated based on the first feature value extracted from the spectrum of the complex dielectric permittivity of the platelet-containing sample, and
the activation residual rate AR (%) is calculated by following equation (1):

OG Complex Work Unit Math
αdbcm: the first feature value extracted from the spectrum of the complex dielectric permittivity of the platelet-containing sample to be measured,
αmax: a second feature value extracted from the spectrum of the complex dielectric permittivity of the platelet-containing sample with the platelet aggregation inhibitor added,
αmin: a third feature value extracted from the spectrum of the complex dielectric permittivity of the platelet-containing sample without the platelet agonist or the platelet aggregation inhibitor added.