	US 11,981,927 B2
	Method for producing liver stem cells or liver progenitor cells by direct reprogramming
Atsushi Suzuki, Fukuoka (JP)
Assigned to KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, Fukuoka (JP)
Appl. No. 16/757,817
Filed by KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, Fukuoka (JP)
PCT Filed Oct. 23, 2018, PCT No. PCT/JP2018/039295 § 371(c)(1), (2) Date Apr. 21, 2020, PCT Pub. No. WO2019/082874, PCT Pub. Date May 2, 2019.
Claims priority of application No. 2017-204432 (JP), filed on Oct. 23, 2017.
Prior Publication US 2021/0189347 A1, Jun. 24, 2021
Int. Cl. C12N 5/071 (2010.01)

CPC C12N 5/0672 (2013.01) [C12N 2501/10 (2013.01); C12N 2506/11 (2013.01); C12N 2506/28 (2013.01)]

10 Claims

1. An in vitro method for inducing conversion from non-hepatic stem cells or non-hepatic progenitor cells into hepatic stem cells or hepatic progenitor cells having proliferation potency, which comprises introducing any of the following combinations into the non-hepatic stem cells or non-hepatic progenitor cells:

(a) a combination consisting of (i) HNF1A, (ii) HNF6 and (iii) FOXA3; or

(b) a combination consisting of (i) HNF1A gene, (ii) HNF6 gene and (iii) FOXA3 gene;

(d) a combination consisting of (i) HNF1A gene, (ii) HNF6 gene, (iii) FOXA3 gene and (iv) L-MYC gene.