US 11,981,886 B2
Biocompatible three-dimensional network and use thereof as a cell support
David Cornu, Prades-le-Lez (FR); Norbert Bakalara, Saint-Martin-de-Londres (FR); Emilie Marhuenda, Montpellier (FR); and Ali Saleh, Montpellier (FR)
Assigned to UNIVERSITE DE MONTPELLIER, Montpellier (FR); INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, Montpellier (FR)
Appl. No. 16/969,497
Filed by UNIVERSITE DE MONTPELLIER, Montpellier (FR); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, Paris (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, Montpellier (FR)
PCT Filed Feb. 15, 2019, PCT No. PCT/EP2019/053883
§ 371(c)(1), (2) Date Aug. 12, 2020,
PCT Pub. No. WO2019/158724, PCT Pub. Date Aug. 22, 2019.
Claims priority of application No. 1851324 (FR), filed on Feb. 16, 2018.
Prior Publication US 2020/0377837 A1, Dec. 3, 2020
Int. Cl. C12M 1/12 (2006.01); C08L 33/18 (2006.01); C12N 5/00 (2006.01); D01D 5/00 (2006.01); D01D 10/02 (2006.01); D01F 6/18 (2006.01); D06M 15/15 (2006.01)
CPC C12M 25/14 (2013.01) [C08L 33/18 (2013.01); C12N 5/0068 (2013.01); D01D 5/0038 (2013.01); D01D 10/02 (2013.01); D01F 6/18 (2013.01); D06M 15/15 (2013.01); C12N 2513/00 (2013.01); C12N 2533/30 (2013.01); C12N 2533/90 (2013.01); C12N 2539/10 (2013.01)] 20 Claims
 
1. An infusible three-dimensional network of crosslinked acrylic-type polymer fibers, wherein:
the diameter of said fibers is comprised between 0.1 and 1.5 μm;
the size of the interstices between said fibers is comprised between 0.1 and 50 μm2; and
the stiffness of said network includes an elastic modulus comprised between 0.01 and 10,000 kPa.