US 11,981,846 B2
Nanocomposite and uses thereof
Michael Hsiao, Taipei (TW); Ming-Hsien Chan, Taipei (TW); Subbiramaniyan Kubendhiran, Taipei (TW); Ming-Che Hsieh, Taipei (TW); Zhen Bao, Changzhou (CN); An-Bang Wang, Taipei (TW); and Ru-Shi Liu, Taipei (TW)
Assigned to ACADEMIA SINICA, Taipei (TW)
Appl. No. 17/611,896
Filed by Academia Sinica, Taipei (TW)
PCT Filed Jul. 29, 2020, PCT No. PCT/US2020/043970
§ 371(c)(1), (2) Date Nov. 16, 2021,
PCT Pub. No. WO2021/021866, PCT Pub. Date Feb. 4, 2021.
Claims priority of provisional application 62/881,384, filed on Aug. 1, 2019.
Prior Publication US 2022/0220370 A1, Jul. 14, 2022
Int. Cl. C09K 11/02 (2006.01); C09K 11/56 (2006.01); C09K 11/70 (2006.01); C09K 11/77 (2006.01); C09K 11/88 (2006.01); G01N 33/58 (2006.01); B82Y 20/00 (2011.01); B82Y 40/00 (2011.01)
CPC C09K 11/025 (2013.01) [C09K 11/565 (2013.01); C09K 11/70 (2013.01); C09K 11/7773 (2013.01); C09K 11/883 (2013.01); G01N 33/587 (2013.01); G01N 33/588 (2013.01); B82Y 20/00 (2013.01); B82Y 40/00 (2013.01); G01N 2458/00 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A nanocomposite comprising,
a core-shell nanoparticle comprising,
a phosphor core, which is made of a first phosphor material doped with one or more emitter ions;
a shell layer encapsulating the phosphor core, wherein the shell layer is made of a second phosphor material doped with one or more absorber ions; and
a cleavable peptide coupled to the shell layer; and
a core-shell quantum dot comprising,
a center core, which is made of indium phosphide (InP), cadmium selenide (CdSe), cadmium selenide sulphide (CdSeS), zinc selenide (ZnSe), zinc cadmium selenide (ZnCdSe), or cadmium telluride (CdTe);
an intermediate layer encapsulating the center core, wherein the intermediate layer is made of cadmium sulphide (CdS), cadmium zinc sulphide (CdZnS), or zinc selenide sulphide (ZnSeS);
an outer layer encapsulating the intermediate layer, wherein the outer layer is made of zinc sulphide (ZnS);
a silica layer encapsulating the outer layer; and
an arginylglycylaspartic acid (RGD) peptide coupled to the silica layer;
wherein the core-shell nanoparticle is linked with the core-shell quantum dot via forming a peptide bond between the cleavable peptide and the RGD peptide.