	US 11,981,746 B2
	MUC16 specific chimeric antigen receptors and uses thereof
Helen Sabzevari, Germantown, MD (US); and Rutul Shah, Germantown, MD (US)
Assigned to PRECIGEN, INC., Germantown, MD (US)
Filed by PRECIGEN, INC., Germantown, MD (US)
Filed on Feb. 4, 2022, as Appl. No. 17/650,018.
Application 17/650,018 is a continuation of application No. 16/431,193, filed on Jun. 4, 2019, granted, now 11,319,380.
Claims priority of provisional application 62/680,297, filed on Jun. 4, 2018.
Prior Publication US 2022/0153866 A1, May 19, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/30 (2006.01); A61K 9/00 (2006.01); A61K 35/17 (2015.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/005 (2006.01); C07K 14/54 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01); C12N 7/00 (2006.01)

CPC C07K 16/3092 (2013.01) [A61K 9/0019 (2013.01); A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/005 (2013.01); C07K 14/5434 (2013.01); C07K 14/5443 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C07K 14/71 (2013.01); C12N 5/0636 (2013.01); C12N 7/00 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C12N 2770/00033 (2013.01)]

81 Claims

1. A nucleic acid encoding a chimeric antigen receptor, wherein the chimeric antigen receptor comprises:

(a) an antigen-binding domain comprising: (i) the amino acid sequence of SEQ ID NO: 5; and (ii) the amino acid sequence of SEQ ID NO: 6;

(b) a transmembrane domain; and