US 11,981,736 B2
Antibodies specific to glycosylated PD-1 and methods of use thereof
Stephen S. Yoo, Centreville, VA (US); Ezra M. Chung, North Potomac, MD (US); Yong-Soo Kim, Rockville, MD (US); Seung-Oe Lim, Houston, TX (US); Chia-Wei Li, Houston, TX (US); and Mien-Chie Hung, Houston, TX (US)
Assigned to ST CUBE INC., Seoul (KR); and BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed by STCUBE, INC., Seoul (KR); and BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed on Nov. 13, 2020, as Appl. No. 17/097,892.
Application 17/097,892 is a continuation of application No. 15/778,663, granted, now 10,858,432, previously published as PCT/US2016/064394, filed on Dec. 1, 2016.
Claims priority of provisional application 62/262,303, filed on Dec. 2, 2015.
Prior Publication US 2021/0139588 A1, May 13, 2021
Int. Cl. C07H 21/04 (2006.01); A61K 9/00 (2006.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 16/44 (2006.01); C12N 5/20 (2006.01); C12N 15/00 (2006.01); C12N 15/87 (2006.01); C12P 21/06 (2006.01)
CPC C07K 16/2818 (2013.01) [A61K 9/0019 (2013.01); A61K 39/395 (2013.01); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); C07K 16/44 (2013.01); C07K 2317/34 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 19 Claims
 
1. A polynucleotide comprising a nucleic acid sequence encoding an antibody which binds to PD-1, wherein said antibody has a VH domain comprising CDRs H1, H2, and H3 having the amino acid sequences of SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8, respectively, or having the amino acid sequences of SEQ ID NO: 9, SEQ ID NO: 10, and SEQ ID NO: 8, respectively, or having the amino acid sequences of SEQ ID NO: 11, SEQ ID NO: 12, and SEQ ID NO: 8, respectively, or having the amino acid sequences of SEQ ID NO: 13, SEQ ID NO: 14, and SEQ ID NO: 15, respectively; and wherein said antibody has a VL domain comprising CDRs L1, L2 and L3 with amino acid sequences of SEQ ID NO: 16, SEQ ID NO: 17, and SEQ ID NO: 18, respectively, or having the amino acid sequences of SEQ ID NO: 19, SEQ ID NO: 20, and SEQ ID NO: 21, respectively.