US 11,981,730 B2
Anti-CXCL13 antibodies and methods of using the same
Ekaterina Klimatcheva, Webster, NY (US); Mark Paris, Mendon, NY (US); and Ernest S. Smith, W. Henrietta, NY (US)
Assigned to Vaccinex, Inc., Rochester, NY (US)
Filed by Vaccinex, Inc., Rochester, NY (US)
Filed on Sep. 24, 2020, as Appl. No. 17/030,627.
Application 17/030,627 is a division of application No. 15/953,139, filed on Apr. 13, 2018, granted, now 10,829,550.
Application 15/953,139 is a division of application No. 13/820,278, granted, now 9,963,504, issued on May 8, 2018, previously published as PCT/US2011/050177, filed on Sep. 1, 2011.
Claims priority of provisional application 61/481,645, filed on May 2, 2011.
Claims priority of provisional application 61/379,672, filed on Sep. 2, 2010.
Prior Publication US 2021/0087263 A1, Mar. 25, 2021
Int. Cl. C07K 16/24 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/24 (2013.01) [A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01)] 12 Claims
 
1. A method for treating an autoimmune disease or an inflammatory disease, comprising administering to a mammal in need of treatment an isolated antibody or antigen-binding fragment thereof that specifically binds to human, murine and cynomolgus monkey CXCL13, wherein the antibody or antigen-binding fragment comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH comprises the three complementarity determining regions HCDR1, HCDR2, HCDR3 of SEQ ID NO: 4, SEQ ID NO. 5, and SEA ID NO:6, respectively, and wherein the VL comprises the LCDR1, LCDR2, and LCDR3 regions of SEQ ID NO: 9, SEQ ID NO: 10, and SEQ ID NO: 11, respectively, or the LCDR1, LCDR2, and LCDR3 regions of SEQ ID NO: 16, SEQ ID NO: 10, and SEQ ID NO: 11, respectively, wherein the autoimmune disease or inflammatory disease is multiple sclerosis (MS), Systemic Lupus Erythematosis (SLE) or arthritis or wherein the inflammatory disease is associated with a Helicobacter bacterial infection.